RNA Polymerase III Subunit E (POLR3E) 抗体
Our Local Distributor
北京 101111
Quick Overview for RNA Polymerase III Subunit E (POLR3E) 抗体 (ABIN7468910)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 人
-
纯化方法
- Purified by antigen-affinity chromatography.
-
免疫原
- Recombinant protein encompassing a sequence within the center region of human POLR3E. The exact sequence is proprietary.
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
-
说明
-
Positive Control: Jurkat
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
-
储存液
- Thimerosal (Merthiolate)
-
注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
- RNA Polymerase III Subunit E (POLR3E)
-
别名
- RNA polymerase III subunit E
-
背景
-
Synonyms: RNA polymerase III subunit E , RPC5 , SIN
Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
-
分子量
- 80 kDa
-
基因ID
- 55718
-
UniProt
- Q9NVU0
抗原
-
