Retinoblastoma Binding Protein 4 抗体 (AA 1-425)
Quick Overview for Retinoblastoma Binding Protein 4 抗体 (AA 1-425) (ABIN7468875)
抗原
See all Retinoblastoma Binding Protein 4 (RBBP4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 1-425
-
交叉反应
- 人
-
纯化方法
- Protein G purified
-
免疫原
- The complete coding region (amino acids 1-425) of RbAp48 expressed in E. coli.
-
亚型
- IgG2b
-
-
-
-
应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
-
说明
-
Positive Control: HeLa nuclear extract , SH-SY-5Y , SH-SY-5Y nuclear extract Validation: Orthogonal
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, No Preservative
-
储存液
- Without preservative
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
- Retinoblastoma Binding Protein 4 (RBBP4)
-
别名
- RB binding protein 4, chromatin remodeling factor
-
背景
-
Synonyms: RB binding protein 4, chromatin remodeling factor , NURF55 , RBAP48 , lin-53
Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
-
分子量
- 48 kDa
-
基因ID
- 5928
-
UniProt
- Q09028
-
途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
抗原
-