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ATRX 抗体 (C-Term)

This anti-ATRX antibody is a 小鼠 单克隆 antibody detecting ATRX in WB, IF 和 ICC. Suitable for 人.
产品编号 ABIN7468429
发货至: 中国

Quick Overview for ATRX 抗体 (C-Term) (ABIN7468429)

抗原

See all ATRX 抗体
ATRX (helicase 2, X-linked (ATRX))

适用

  • 73
  • 17
  • 4
  • 3
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  • 2

宿主

  • 44
  • 31
  • 1
小鼠

克隆类型

  • 45
  • 31
单克隆

标记

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  • 3
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  • 2
  • 1
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This ATRX antibody is un-conjugated

应用范围

  • 29
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Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

克隆位点

GT4212
  • 抗原表位

    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
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    C-Term

    交叉反应

    人, 小鼠

    纯化方法

    Affinity purified by Protein G.

    免疫原

    Recombinant protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary.

    亚型

    IgG1
  • 应用备注

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: Neuro2A , C8D30 , BCL-1 , 293T Validation: KO/KD, Orthogonal, Overexpression

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS, No Preservative

    储存液

    Without preservative

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    ATRX (helicase 2, X-linked (ATRX))

    别名

    ATRX chromatin remodeler

    背景

    Synonyms: ATRX chromatin remodeler , JMS , MRX52 , RAD54 , RAD54L , XH2 , XNP , ZNF-HX

    Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

    分子量

    283 kDa

    基因ID

    546

    UniProt

    P46100
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