IMPA1 抗体
Quick Overview for IMPA1 抗体 (ABIN7467238)
抗原
See all IMPA1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
 - 人
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纯化方法
 - Purified by antigen-affinity chromatography.
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免疫原
 - Full length human IMPA1 Recombinant protein.
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亚型
 - IgG
 
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应用备注
 - WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: PC-3 , SK-N-SH
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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储存液
 - Thimerosal (Merthiolate)
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注意事项
 - This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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- IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
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别名
 - inositol monophosphatase 1
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背景
 - Inositol monophosphatase 1 , IMP , IMPA , MRT59,This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq]
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分子量
 - 30 kDa
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基因ID
 - 3612
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UniProt
 - P29218
 
抗原
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