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Cullin 5 抗体 (N-Term)

The 兔 多克隆 anti-Cullin 5 antibody is suitable to detect Cullin 5 in samples from 人. It has been validated for WB, IF, IHC (p) 和 ICC.
产品编号 ABIN7467004
发货至: 中国
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Quick Overview for Cullin 5 抗体 (N-Term) (ABIN7467004)

抗原

See all Cullin 5 (CUL5) 抗体
Cullin 5 (CUL5)

适用

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宿主

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克隆类型

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多克隆

标记

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This Cullin 5 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
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    N-Term

    交叉反应

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the N-terminus region of human Cullin 5. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: NT2D1

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.91 mg/mL

    缓冲液

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    Cullin 5 (CUL5)

    别名

    cullin 5

    背景

    Cullin 5 , CUL-5 , VACM-1 , VACM1,Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

    分子量

    91 kDa

    基因ID

    8065

    UniProt

    Q93034

    途径

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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