RFWD3 抗体 (C-Term)
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北京 101111
Quick Overview for RFWD3 抗体 (C-Term) (ABIN7466618)
抗原
See all RFWD3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human RFWD3. The exact sequence is proprietary.
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亚型
- IgG
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anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (N-Term) antibody
RFWD3 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (Internal Region) antibodyRFWD3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 3 (RFWD3) (AA 651-749) antibodyRFWD3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6B4 unconjugated
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应用备注
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: MCF-7
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.96 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))
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别名
- ring finger and WD repeat domain 3
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背景
- Ring finger and WD repeat domain 3 , FANCW , RNF201,E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
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分子量
- 85 kDa
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基因ID
- 55159
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UniProt
- Q6PCD5
抗原
-
