USP33 抗体 (C-Term)
Quick Overview for USP33 抗体 (C-Term) (ABIN7466082)
抗原
See all USP33 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 人
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human USP33. The exact sequence is proprietary.
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 327-426) antibody
USP33 适用: 人 ELISA, WB, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) antibodyUSP33 适用: 人, 小鼠, 大鼠 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 290-400) antibodyUSP33 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 251-550), (C-Term) antibodyUSP33 适用: 人 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 327-427) antibodyUSP33 适用: 人 ELISA, IHC, WB, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B5 unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (Internal Region) antibodyUSP33 适用: 人, Cow, 犬, 兔, 马, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 1-911) antibodyUSP33 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 33 (USP33) (AA 799-829) antibodyUSP33 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: HepG2
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- USP33 (Ubiquitin Specific Peptidase 33 (USP33))
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别名
- ubiquitin specific peptidase 33
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背景
- Ubiquitin specific peptidase 33 , VDU1,Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
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分子量
- 107 kDa
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基因ID
- 23032
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UniProt
- Q8TEY7
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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