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LAT 抗体 (C-Term)

This anti-LAT antibody is a 兔 多克隆 antibody detecting LAT in WB 和 IHC (p). Suitable for 人.
产品编号 ABIN7464676
发货至: 中国

Quick Overview for LAT 抗体 (C-Term) (ABIN7464676)

抗原

See all LAT 抗体
LAT (Linker For Activation of T Cells (LAT))

适用

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宿主

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克隆类型

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多克隆

标记

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This LAT antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    C-Term

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human LAT. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: Jurkat membrane extract

    Validation: Comparison, Orthogonal

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1.41 mg/mL

    缓冲液

    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    LAT (Linker For Activation of T Cells (LAT))

    别名

    linker for activation of T cells

    背景

    Linker for activation of T cells , IMD52 , LAT1 , pp36,The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

    分子量

    28 kDa

    基因ID

    27040

    UniProt

    O43561

    途径

    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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