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CD22 抗体

The 小鼠 单克隆 anti-CD22 antibody (Clone Cy34-1) (ABIN7457864) specifically detects CD22 in FACS. The antibody is reactive with 小鼠 samples.
产品编号 ABIN7457864
发货至: 中国
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北京 101111
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Room 801-803
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Quick Overview for CD22 抗体 (ABIN7457864)

抗原

See all CD22 抗体
CD22 (CD22 Molecule (CD22))

适用

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小鼠

宿主

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小鼠

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单克隆

标记

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This CD22 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)

克隆位点

Cy34-1
  • 纯化方法

    Purified

    过滤

    0.2 μm filtered

    内毒素水平

    Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Matching Isotype Control: AF/LE Purified Mouse IgG1, κ Isotype Control (ABIN7469767)

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)

    储存液

    Azide free

    储存条件

    4 °C

    储存方法

    Store at 2~8°C. Do not freeze.
  • 抗原

    CD22 (CD22 Molecule (CD22))

    别名

    CD22

    背景

    B-cell receptor CD22,Cd22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,CD22,Lyb-8, Siglec2,The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig μ chain are augmented in the presence of Cy34.1 mAb.

    基因ID

    12483

    UniProt

    P35329
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