BAG3 抗体 (AA 525-575)
Quick Overview for BAG3 抗体 (AA 525-575) (ABIN7454868)
抗原
See all BAG3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 525-575
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原理
- Rabbit anti-BAG3 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 525 and 575
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亚型
- IgG
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应用备注
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IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- BAG3 (BCL2-Associated Athanogene 3 (BAG3))
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别名
- BAG3
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背景
- Background: BAG3 (BCL2-associated athanogene 3) BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. BAG3 contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner [taken from NCBI Entrez Gene (Gene ID: 9531)].
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基因ID
- 9531
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NCBI登录号
- NP_004272
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UniProt
- O95817
抗原
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