KDM5B 抗体 (AA 1494-1544)
Quick Overview for KDM5B 抗体 (AA 1494-1544) (ABIN7454788)
抗原
See all KDM5B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1494-1544
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原理
- Rabbit anti-JARID1B Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 1494 and 1544
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))
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别名
- JARID1B
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背景
- Background: JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer.
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基因ID
- 10765
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NCBI登录号
- NP_006609
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UniProt
- Q9UGL1
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途径
- Warburg Effect
抗原
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