Claspin 抗体 (AA 725-775)
Quick Overview for Claspin 抗体 (AA 725-775) (ABIN7454603)
抗原
See all Claspin (CLSPN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 725-775
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原理
- Rabbit anti-Claspin Antibody, Affinity Purified
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预测反应
- Orangutan,Gorilla,Chimpanzee
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纯化方法
- Affinity Purified
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免疫原
- between AA 725 and 775
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亚型
- IgG
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anti-Claspin (CLSPN) (N-Term) antibody
CLSPN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Claspin (CLSPN) (AA 650-750) antibodyCLSPN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 1 - 5 μg/mg lysate
WB: 1:500 - 1:2,500
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Claspin (CLSPN)
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别名
- Claspin
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背景
- Background: Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.
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基因ID
- 63967
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UniProt
- Q9HAW4
抗原
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