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DNMT3A 抗体 (AA 125-175)

The 兔 多克隆 anti-DNMT3A antibody is suitable to detect DNMT3A in samples from 人 和 小鼠. It has been validated for WB 和 IHC (fp).
产品编号 ABIN7454575
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for DNMT3A 抗体 (AA 125-175) (ABIN7454575)

抗原

See all DNMT3A 抗体
DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

适用

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人, 小鼠

宿主

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克隆类型

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  • 40
多克隆

标记

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This DNMT3A antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

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    AA 125-175

    原理

    Rabbit anti-DNMT3A Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    Between AA 125 and 175

    亚型

    IgG
  • 应用备注

    IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: Not recommended

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

    别名

    DNMT3A

    背景

    Background: DNA cytosine methyltransferase 3A2 (DNMT3A) is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3A modifies DNA in a non-processive manner and also methylates non-CpG sites. It may preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. DNMT3A plays a role in paternal and maternal imprinting and is required for methylation of most imprinted loci in germ cells [taken from the Universal Protein Resource (UniProt) Q9Y6K1].

    基因ID

    1788

    NCBI登录号

    NP_783328

    UniProt

    Q9Y6K1
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