TXNIP 抗体 (AA 300-350)
Quick Overview for TXNIP 抗体 (AA 300-350) (ABIN7454484)
抗原
See all TXNIP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 300-350
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原理
- Rabbit anti-TXNIP Antibody, Affinity Purified
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预测反应
- Rat
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纯化方法
- Affinity Purified
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免疫原
- between AA 300 and 350
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: Not recommended
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- TXNIP (Thioredoxin Interacting Protein (TXNIP))
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别名
- TXNIP
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背景
- Background: Thioredoxin-interacting protein (TXNIP) may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. TXNIP interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Also, TXNIP functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest [taken from the Universal Protein Resource (UniProt) Q9H3M7].
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基因ID
- 10628
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NCBI登录号
- NP_006463
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UniProt
- Q9H3M7
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途径
- Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome
抗原
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