UBR4 抗体 (AA 150-200)
Quick Overview for UBR4 抗体 (AA 150-200) (ABIN7454442)
抗原
See all UBR4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 150-200
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原理
- Rabbit anti-p600 Antibody, Affinity Purified
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预测反应
- Mouse,Rat
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纯化方法
- Affinity Purified
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免疫原
- between AA 150 and 200
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 10 μg/mg lysate
WB: Not recommended. Use rabbit anti-p600 antibody A302-278A or A302-279A.
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))
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别名
- p600
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背景
- Background: p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) Q5T4S7].
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基因ID
- 23352
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NCBI登录号
- NP_065816
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UniProt
- Q5T4S7
抗原
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