FLII 抗体 (AA 425-475)
Quick Overview for FLII 抗体 (AA 425-475) (ABIN7453708)
抗原
See all FLII 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 425-475
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原理
- Rabbit anti-Flightless-1 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 425 and 475
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亚型
- IgG
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应用备注
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IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- FLII (Flightless I Homolog (FLII))
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别名
- Flightless-1
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背景
- Background: Flightless-1 is the human homolog of the drosophila flightless (fli1), a gene required for proper development of flight muscles and essential to embryonic development. It is a member of the gelsolin family of actin-binding proteins, and is highly conserved among vertebrates and invertebrates. The actin-remodeling activity of flightless-1 may have multiple roles in the cell. Studies in transgenic mice indicate a role in wound healing that may involve the regulation of cell migration and proliferation. Flightless-1 has also been found to be associated with complexes involved in transcriptional regulation. It associates with CARM1, a protein arginine methyltransferase, and may function as a nuclear receptor coactivator via this interaction. It has also been shown to associate with the BAF53a subunit of the SWI/SNF-like chromatin remodeling complexes.
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基因ID
- 2314
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NCBI登录号
- NP_002009
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UniProt
- Q13045
抗原
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