Cyclin T1 抗体 (AA 250-300)
Quick Overview for Cyclin T1 抗体 (AA 250-300) (ABIN7453622)
抗原
See all Cyclin T1 (CCNT1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 250-300
-
原理
- Rabbit anti-Cyclin T1 Antibody, Affinity Purified
-
预测反应
- Chimpanzee
-
纯化方法
- Affinity Purified
-
免疫原
- between AA 250 and 300
-
亚型
- IgG
-
-
-
-
应用备注
-
IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- Cyclin T1 (CCNT1)
-
别名
- Cyclin T1
-
背景
- Background: Cyclin T1 is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, Cyclin T1 binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA) [taken from the Universal Protein Resource (UniProt) O60563].
-
基因ID
- 904
-
NCBI登录号
- NP_001231
-
UniProt
- O60563
抗原
-