NOC2L 抗体 (AA 699-749)
Quick Overview for NOC2L 抗体 (AA 699-749) (ABIN7453539)
抗原
See all NOC2L 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 699-749
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原理
- Rabbit anti-NIR Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 699 and 749
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亚型
- IgG
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anti-Nucleolar Complex Associated 2 Homolog (NOC2L) antibody
NOC2L 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolar Complex Associated 2 Homolog (NOC2L) (C-Term) antibodyNOC2L 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: Not recommended
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))
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别名
- NIR
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背景
- Background: Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity, it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) Q9Y3T9].
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基因ID
- 26155
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NCBI登录号
- NP_056473
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UniProt
- Q9Y3T9
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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