Geminin 抗体 (C-Term)
Quick Overview for Geminin 抗体 (C-Term) (ABIN7453481)
抗原
See all Geminin (GMNN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Rabbit anti-Geminin Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 160 and C-term
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亚型
- IgG
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应用备注
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
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别名
- Geminin
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背景
- Background: Geminin has been identified as a protein that inhibits DNA replication during S, G2, and M phases in association with Cdt1 (chromatin licensing and DNA replication factor). Geminin prevents the binding of the MCM complex onto origins of replication, and its abundance is regulated by ubiquitin ligase activity of the APC/C (anaphase-promoting/cyclosome) complex.
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基因ID
- 51053
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NCBI登录号
- NP_056979
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UniProt
- O75496
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途径
- EGFR Signaling Pathway, DNA Replication
抗原
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