THO Complex 4 抗体 (AA 25-75)
Quick Overview for THO Complex 4 抗体 (AA 25-75) (ABIN7453477)
抗原
See all THO Complex 4 (THOC4) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 25-75
-
原理
- Rabbit anti-Aly Antibody, Affinity Purified
-
预测反应
- Bovine
-
纯化方法
- Affinity Purified
-
免疫原
- between AA 25 and 75
-
亚型
- IgG
-
-
-
-
应用备注
-
IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
-
限制
- 仅限研究用
-
-
-
浓度
- 1000 μg/mL
-
缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- THO Complex 4 (THOC4)
-
别名
- Aly
-
背景
- Background: Aly (ally of AML-1 and LEF-1) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. Aly also functions as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Additionally, Aly plays a role in mRNA processing and export and may function as scaffold that mediates interactions between proteins and/or RNA. Aly is also part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Aly directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway [taken from the Universal Protein Resource (UniProt) Q886V81].
-
基因ID
- 10189
-
UniProt
- Q86V81
抗原
-