PCNT 抗体 (AA 175-225)
Quick Overview for PCNT 抗体 (AA 175-225) (ABIN7453380)
抗原
See all PCNT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 175-225
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原理
- Rabbit anti-Pericentrin/Kendrin Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 175 and 225
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亚型
- IgG
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anti-Pericentrin (PCNT) (AA 2987-3246) antibody
PCNT 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Pericentrin (PCNT) (AA 250-600) antibodyPCNT 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pericentrin (PCNT) antibodyPCNT 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ICC-IF: 1:1,000 - 1:5,000. Formaldehyde or Acetone fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- PCNT (Pericentrin (PCNT))
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别名
- Pericentrin/Kendrin
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背景
- Background: Pericentrin (PCNT) is a large centrosomal protein that binds calmodulin and mediates assembly of the mitotic spindle apparatus. Depletion of PCNT has been shown to cause apoptosis and activation of the G2/M checkpoint. Recently, mutations in the pericentrin gene have been identified as the cause of primordial dwarfism type II (MOPDII) and Seckel syndrome. Additionally, in cells of Seckel syndrome patients, PCNT has been found to be important to the DNA damage response and ATR-dependent checkpoint signaling.
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基因ID
- 5116
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NCBI登录号
- NP_006022
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UniProt
- O95613
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途径
- Sensory Perception of Sound, M Phase, SARS-CoV-2 Protein Interactome
抗原
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