Transferrin Receptor 抗体 (AA 125-175)
Quick Overview for Transferrin Receptor 抗体 (AA 125-175) (ABIN7453217)
抗原
See all Transferrin Receptor (TFRC) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 125-175
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原理
- Rabbit anti-TfR Antibody, Affinity Purified
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预测反应
- Dog,Horse,Orangutan
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纯化方法
- Affinity Purified
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免疫原
- Between AA 125 and 175
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亚型
- IgG
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应用备注
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IP: Not recommended
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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别名
- TfR
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背景
- Background: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) P02786].
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基因ID
- 7037
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NCBI登录号
- NP_003225
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UniProt
- P02786
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途径
- Transition Metal Ion Homeostasis
抗原
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