ALS2 抗体 (AA 1250-1300)
Quick Overview for ALS2 抗体 (AA 1250-1300) (ABIN7453027)
抗原
See all ALS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1250-1300
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原理
- Rabbit anti-Alsin Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 1250 and 1300
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亚型
- IgG
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应用备注
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IP: Not recommended
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))
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别名
- Alsin
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背景
- Background: Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. Alsin localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in the gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis [taken from NCBI Entrez Gene (Gene ID: 57679)].
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基因ID
- 57679
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NCBI登录号
- NP_065970
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UniProt
- Q96Q42
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途径
- Skeletal Muscle Fiber Development
抗原
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