ZNF207 抗体 (AA 428-478)
Quick Overview for ZNF207 抗体 (AA 428-478) (ABIN7452845)
抗原
See all ZNF207 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 428-478
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原理
- Rabbit anti-ZNF207 Antibody, Affinity Purified
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预测反应
- Orangutan
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纯化方法
- Affinity Purified
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免疫原
- between AA 428 and 478
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亚型
- IgG
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应用备注
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- ZNF207 (Zinc Finger Protein 207 (ZNF207))
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别名
- ZNF207
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背景
- Background: ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) O43670].
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基因ID
- 7756
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UniProt
- O43670
抗原
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