Sestrin 2 抗体 (AA 275-325)
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Quick Overview for Sestrin 2 抗体 (AA 275-325) (ABIN7452840)
抗原
See all Sestrin 2 (SESN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 275-325
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原理
- Rabbit anti-SESN2 Antibody, Affinity Purified
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预测反应
- Mouse,Orangutan
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纯化方法
- Affinity Purified
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免疫原
- between AA 275 and 325
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亚型
- IgG
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anti-Sestrin 2 (SESN2) (AA 1-480) antibody
SESN2 适用: 人 WB, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Sestrin 2 (SESN2) (AA 1-480) antibodySESN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Sestrin 2 (SESN2) (AA 41-480) antibodySESN2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 211-480) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 42-61) antibodySESN2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 1-480) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 268-317) antibodySESN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (N-Term) antibodySESN2 适用: 人, Cow, 犬, 豚鼠, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (C-Term) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (N-Term) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Sestrin 2 (SESN2)
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别名
- SESN2
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背景
- Background: SESN2 functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. SESN2 may negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1, and may positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress, and has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. [taken from the Universal Protein Resource (UniProt) P58004].
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基因ID
- 83667
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UniProt
- P58004
抗原
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