LAT 抗体 (AA 212-262)
Quick Overview for LAT 抗体 (AA 212-262) (ABIN7452825)
抗原
See all LAT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 212-262
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原理
- Rabbit anti-LAT Antibody, Affinity Purified
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预测反应
- Mouse,Rat
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纯化方法
- Affinity Purified
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免疫原
- between AA 212 and 262
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亚型
- IgG
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应用备注
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- LAT (Linker For Activation of T Cells (LAT))
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别名
- LAT
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背景
- Background: LAT is required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. [taken from the Universal Protein Resource (UniProt) O43561].
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基因ID
- 27040
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UniProt
- O43561
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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