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CCDC22 抗体 (AA 577-627)

This anti-CCDC22 antibody is a 兔 多克隆 antibody detecting CCDC22 in WB 和 IP. Suitable for 人 和 小鼠.
产品编号 ABIN7452809
发货至: 中国

Quick Overview for CCDC22 抗体 (AA 577-627) (ABIN7452809)

抗原

See all CCDC22 抗体
CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))

适用

  • 18
  • 18
  • 14
人, 小鼠

宿主

  • 29

克隆类型

  • 29
多克隆

标记

  • 10
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CCDC22 antibody is un-conjugated

应用范围

  • 29
  • 13
  • 13
  • 12
  • 11
  • 6
  • 3
  • 2
  • 1
Western Blotting (WB), Immunoprecipitation (IP)
  • 抗原表位

    • 15
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 577-627

    原理

    Rabbit anti-CCDC22 Antibody, Affinity Purified

    预测反应

    Bovine

    纯化方法

    Affinity Purified

    免疫原

    between AA 577 and 627

    亚型

    IgG
  • 应用备注

    IP: 50-100 μL/mg lysate

    WB: 1:10,000 - 1:25,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))

    别名

    CCDC22

    背景

    Background: CCDC22 is involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation, the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. [taken from the Universal Protein Resource (UniProt) O60826].

    基因ID

    28952

    UniProt

    O60826
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