CNOT1 抗体 (AA 1400-1450)
Quick Overview for CNOT1 抗体 (AA 1400-1450) (ABIN7452794)
抗原
See all CNOT1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1400-1450
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原理
- Rabbit anti-CNOT1 Antibody, Affinity Purified
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预测反应
- Zebrafish,X. tropicalis
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纯化方法
- Affinity Purified
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免疫原
- between AA 1400 and 1450
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亚型
- IgG
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anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 604-867) antibody
CNOT1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 2137-2376) antibodyCNOT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 595-744) antibodyCNOT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IP: 50 - 100 μL/mg lysate
WB: 1:10,000 - 1:25,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
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别名
- CNOT1
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背景
- Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) A5YKK6].
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基因ID
- 23019
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UniProt
- A5YKK6
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途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
抗原
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