LYN 抗体 (AA 1-50)
Quick Overview for LYN 抗体 (AA 1-50) (ABIN7452765)
抗原
See all LYN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50
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原理
- Rabbit anti-LYN Antibody, Affinity Purified
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预测反应
- Rat
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纯化方法
- Affinity Purified
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免疫原
- between AA 1 and 50
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亚型
- IgG
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应用备注
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IP: 5 - 15 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
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别名
- LYN
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背景
- Background: LYN is a tyrosine protein kinase that acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. It is involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents. LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism [taken from the Universal Protein Resource (UniProt) P07948].
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基因ID
- 4067
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NCBI登录号
- NP_002341
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UniProt
- P07948
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途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling
抗原
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