Huntingtin 抗体 (AA 2300-2350)
Quick Overview for Huntingtin 抗体 (AA 2300-2350) (ABIN7452517)
抗原
See all Huntingtin (HTT) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 2300-2350
-
原理
- Rabbit anti-Huntingtin Antibody, Affinity Purified
-
纯化方法
- Affinity Purified
-
免疫原
- between AA 2300 and 2350
-
亚型
- IgG
-
-
-
-
应用备注
-
IP: 2 - 5 μg/mg lysate
WB: Not recommended
-
限制
- 仅限研究用
-
-
-
浓度
- 1000 μg/mL
-
缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
有效期
- 12 months
-
-
- Huntingtin (HTT)
-
别名
- Huntingtin
-
背景
- Background: The Huntingtin (HTT) gene is linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene product is widely expressed and is required for normal development [taken from NCBI Entrez Gene (Gene ID: 3064)].
-
基因ID
- 3064
-
NCBI登录号
- NP_002102
-
UniProt
- P42858
-
途径
- PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport
抗原
-