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ZAP70 抗体 (pTyr493, pTyr494)

This anti-ZAP70 antibody is a 兔 多克隆 antibody detecting ZAP70 in IP. Suitable for 人.
产品编号 ABIN7452236
发货至: 中国

Quick Overview for ZAP70 抗体 (pTyr493, pTyr494) (ABIN7452236)

抗原

See all ZAP70 抗体
ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

适用

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宿主

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克隆类型

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多克隆

标记

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This ZAP70 antibody is un-conjugated

应用范围

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Immunoprecipitation (IP)
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    pTyr493, pTyr494

    原理

    Rabbit anti-Phospho ZAP70 (Y493/Y494) Antibody, Affinity Purified

    预测反应

    Mouse

    纯化方法

    Affinity Purified

    免疫原

    surrounding tyrosine 493/494

    亚型

    IgG
  • 应用备注

    IP: 2 - 5 μg/mg lysate

    WB: Not recommended. ABIN7452236 has not performed satisfactorily when used for WB of phospho ZAP70 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of ZAP70.

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

    别名

    ZAP70

    背景

    Background: ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation.

    基因ID

    7535

    NCBI登录号

    NP_001070

    UniProt

    P43403

    途径

    TCR Signaling, Ubiquitin Proteasome Pathway
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