ZAP70 抗体 (pTyr493, pTyr494)
Quick Overview for ZAP70 抗体 (pTyr493, pTyr494) (ABIN7452236)
抗原
See all ZAP70 抗体适用
宿主
克隆类型
标记
应用范围
- 
    
- 
                                            
抗原表位
 - pTyr493, pTyr494
 - 
                                            
原理
 - Rabbit anti-Phospho ZAP70 (Y493/Y494) Antibody, Affinity Purified
 - 
                                            
预测反应
 - Mouse
 - 
                                            
纯化方法
 - Affinity Purified
 - 
                                            
免疫原
 - surrounding tyrosine 493/494
 - 
                                            
亚型
 - IgG
 
 - 
                                            
 - 
    
 - 
    
- 
                                            
应用备注
 - 
                        
IP: 2 - 5 μg/mg lysate
WB: Not recommended. ABIN7452236 has not performed satisfactorily when used for WB of phospho ZAP70 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of ZAP70.
 - 
                                            
限制
 - 仅限研究用
 
 - 
                                            
 - 
    
- 
                                            
浓度
 - 1000 μg/mL
 - 
                                            
缓冲液
 - Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
 - 
                                            
储存液
 - Sodium azide
 - 
                                            
注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
 - 
                                            
储存条件
 - 4 °C
 - 
                                            
有效期
 - 12 months
 
 - 
                                            
 - 
    
- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
 - 
                                            
别名
 - ZAP70
 - 
                                            
背景
 - Background: ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation.
 - 
                                            
基因ID
 - 7535
 - 
                                            
NCBI登录号
 - NP_001070
 - 
                                            
UniProt
 - P43403
 - 
                                            
途径
 - TCR Signaling, Ubiquitin Proteasome Pathway
 
抗原
 -