USP20 抗体 (AA 863-913)
Quick Overview for USP20 抗体 (AA 863-913) (ABIN7452141)
抗原
See all USP20 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 863-913
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原理
- Rabbit anti-USP20/VDU2 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 863 and 913
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亚型
- IgG
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应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
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别名
- USP20/VDU2
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背景
- Background: The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific peptidase 20 (USP20) is a UBP and is also called von-Hippel-Lindau protein (pVHL) interacting deubiquitinating enzyme 2 (VDU2). pVHL is an E3 ubiquitin-ligase that ubiquitinates hypoxia-inducible factor (HIF)-1alpha. USP20/VDU2 functions to specifically deubiquitinate HIF-1alpha to increase expression of HIF-1alpha regulated genes.
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基因ID
- 10868
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NCBI登录号
- NP_006667
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UniProt
- Q9Y2K6
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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