SIRT6 抗体 (AA 305-355)
Quick Overview for SIRT6 抗体 (AA 305-355) (ABIN7451598)
抗原
See all SIRT6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 305-355
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原理
- Rabbit anti-Sirt6 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 305 and 355
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亚型
- IgG
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应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:1,000 - 1:5,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- SIRT6 (Sirtuin 6 (SIRT6))
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别名
- Sirt6
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背景
- Background: Sirtuin 6 (Sirt6) is a NAD-dependent protein deacetylase. Sirt6 displays deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Sirt6 also deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Sirt6 is important for the modulation of cellular senescence and apoptosis and the maintenance of telomeres and genomic stability [taken from the Universal Protein Resource (UniProt) Q8N6T7].
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基因ID
- 51548
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NCBI登录号
- NP_057623
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UniProt
- Q8N6T7
抗原
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