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IMPA1 抗体 (AA 25-75)

This 兔 多克隆 anti-IMPA1 antibody specifically detects IMPA1 in IP. The antibody is reactive with 人 samples.
产品编号 ABIN7451266
发货至: 中国
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Quick Overview for IMPA1 抗体 (AA 25-75) (ABIN7451266)

抗原

See all IMPA1 抗体
IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

适用

  • 34
  • 15
  • 13
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1

宿主

  • 30
  • 4

克隆类型

  • 31
  • 3
多克隆

标记

  • 16
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This IMPA1 antibody is un-conjugated

应用范围

  • 15
  • 8
  • 7
  • 6
  • 6
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
Immunoprecipitation (IP)
  • 抗原表位

    • 12
    • 1
    • 1
    • 1
    AA 25-75

    原理

    Rabbit anti-IMPA1 Antibody, Affinity Purified

    预测反应

    Orangutan

    纯化方法

    Affinity Purified

    免疫原

    Between AA 25 and 75

    亚型

    IgG
  • 应用备注

    IP: 2 - 10 μg/mg lysate

    WB: Not recommended. Use rabbit anti-IMPA1 antibody ABIN7450359.

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

    别名

    IMPA1

    背景

    Background: Inositol monophosphatase 1 (IMPA1) is an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorde [taken from NCBI Entrez Gene (Gene ID: 3612)].

    基因ID

    3612

    UniProt

    P29218
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