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Nischarin 抗体 (AA 1100-1150)

This anti-Nischarin antibody is a 兔 多克隆 antibody detecting Nischarin in IP. Suitable for 人.
产品编号 ABIN7451170
发货至: 中国

Quick Overview for Nischarin 抗体 (AA 1100-1150) (ABIN7451170)

抗原

See all Nischarin (NISCH) 抗体
Nischarin (NISCH)

适用

  • 11
  • 6
  • 1

宿主

  • 11
  • 4

克隆类型

  • 11
  • 4
多克隆

标记

  • 15
This Nischarin antibody is un-conjugated

应用范围

  • 14
  • 9
  • 9
  • 7
  • 5
  • 1
Immunoprecipitation (IP)
  • 抗原表位

    • 3
    • 3
    • 1
    • 1
    • 1
    AA 1100-1150

    原理

    Rabbit anti-NISCH Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    Between AA 1100 and 1150

    亚型

    IgG
  • 应用备注

    IP: 2 - 10 μg/mg lysate

    WB: Not recommended. ABIN7451170 has not performed satisfactorily when used for WB of NISCH in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of NISCH.

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    Nischarin (NISCH)

    别名

    NISCH

    背景

    Background: Nischarin (NISCH) is a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of NISCH was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation[taken from NCBI Entrez Gene (Gene ID: 11188)].

    基因ID

    11188

    UniProt

    Q9Y2I1
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