SPRY2 抗体 (AA 265-315)
Quick Overview for SPRY2 抗体 (AA 265-315) (ABIN7451050)
抗原
See all SPRY2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 265-315
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原理
- Rabbit anti-Sprouty 2 Antibody, Affinity Purified
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预测反应
- Mouse,Bovine
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纯化方法
- Affinity Purified
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免疫原
- between AA 265 and 315
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: Not recommended. ABIN7451050 has not performed satisfactorily when used for WB of Sprouty 2 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of Sprouty 2.
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- SPRY2 (Sprouty Homolog 2 (SPRY2))
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别名
- Sprouty 2
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背景
- Background: Sprouty 2 contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells sprouty 2 is transiently upregulated in response to fibroblast growth factor two. Sprouty 2 is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. Sprouty 2 interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. Sprouty 2 may play a role in alveoli branching during lung development as shown by a similar mouse protein [taken from NCBI Entrez Gene (Gene ID: 10253)].
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基因ID
- 10253
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NCBI登录号
- NP_005833
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UniProt
- O43597
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途径
- EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation
抗原
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