MRGPRX1/3/4 (AA 21-120) 抗体 (HRP)
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北京 101111
Quick Overview for MRGPRX1/3/4 (AA 21-120) 抗体 (HRP) (ABIN718760)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-120
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特异性
- This may preferentially target MRGPRX1 over 3 and 4 due to slightly higher sequence similarity.
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MRGX1
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亚型
- IgG
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anti-MRGPRX1/3/4 (AA 21-120) antibody
适用: 人 IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- MRGPRX1/3/4
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背景
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Synonyms: MRGPRC, G protein coupled receptor MRGX1, G protein coupled receptor SNSR3, GPCR, Mas related G protein coupled receptor member X1, MAS related gene MRGX1, MAS related GPR member X1, MRGPRX1, MRGX1, Sensory neuron specic G protein coupled receptor 3/4, Seven transmembrane helix receptor, SNSR3, SNSR4, MRGX1_HUMAN, MRGPRX3, MRGX3, MRGPRX4, MRGX4, SNSR5, SNSR6, SNSR1, SNSR2.
Background: There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.
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基因ID
- 259249, 117195, 117196
抗原
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