PNP 抗体 (AA 239-289)
Quick Overview for PNP 抗体 (AA 239-289) (ABIN7450576)
抗原
See all PNP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 239-289
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原理
- Rabbit anti-PNP Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 239 and 289
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- PNP (Purine Nucleoside Phosphorylase (PNP))
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别名
- PNP
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物质类
- Viral Protein
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背景
- Background: Purine nucleoside phosphorylase (PNP) is an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The PNP enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described [taken from NCBI Entrez Gene (Gene ID: 4860)].
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基因ID
- 4860
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NCBI登录号
- NP_000261
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UniProt
- P00491
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus
抗原
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