PAN3 抗体 (AA 175-225)
Quick Overview for PAN3 抗体 (AA 175-225) (ABIN7450539)
抗原
See all PAN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 175-225
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原理
- Rabbit anti-PAN3 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- Between AA 175 and 225
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亚型
- IgG
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anti-PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3) (AA 771-799), (C-Term) antibody
PAN3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB25565 unconjugated
anti-PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3) (AA 727-755), (C-Term) antibodyPAN3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB34660 unconjugated
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))
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别名
- PAN3
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背景
- Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) Q58A45].
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基因ID
- 255967
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UniProt
- Q58A45
抗原
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