FOXO1 抗体 (C-Term)
Quick Overview for FOXO1 抗体 (C-Term) (ABIN7450261)
抗原
See all FOXO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Rabbit anti-FOXO1a Antibody, Affinity Purified
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预测反应
- Mouse,Rat,Bovine,Pig
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纯化方法
- Affinity Purified
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免疫原
- between AA 600 and C-term
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- FOXO1 (Forkhead Box O1 (FOXO1))
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别名
- FOXO1a
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背景
- Background: Forkhead box protein 01A (FOXO1a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO1 is a transcription factor that integrates cell signals to mediate metabolism, the cell cycle, DNA repair, and response to cellular stress. In response to insulin, FOXO1 is phosphorylated by Akt and excluded from the nucleus and subsequently degraded. Over-expressed cytoplasmic FOXO1 interacts with TSC2 to cause its degradation and subsequent activation of the mTOR pathway, while nuclear localization inhibits the mTOR pathway.
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基因ID
- 2308
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NCBI登录号
- NP_002006
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UniProt
- Q12778
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途径
- PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
抗原
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