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ATR 抗体 (AA 400-450)

This anti-ATR antibody is a 兔 多克隆 antibody detecting ATR in WB 和 IP. Suitable for 人.
产品编号 ABIN7450015
发货至: 中国

Quick Overview for ATR 抗体 (AA 400-450) (ABIN7450015)

抗原

See all ATR 抗体
ATR (ATR serine/threonine kinase (ATR))

适用

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宿主

  • 43
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克隆类型

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多克隆

标记

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This ATR antibody is un-conjugated

应用范围

  • 30
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Western Blotting (WB), Immunoprecipitation (IP)
  • 抗原表位

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    AA 400-450

    原理

    Rabbit anti-ATR Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    between AA 400 and 450

    亚型

    IgG
  • 应用备注

    IP: 2 - 10 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    ATR (ATR serine/threonine kinase (ATR))

    别名

    ATR

    背景

    Background: ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.

    基因ID

    545

    NCBI登录号

    NP_001175

    UniProt

    Q13535

    途径

    Positive Regulation of Response to DNA Damage Stimulus
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