ATR 抗体 (AA 400-450)
Quick Overview for ATR 抗体 (AA 400-450) (ABIN7450015)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 400-450
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原理
- Rabbit anti-ATR Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 400 and 450
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- ATR (ATR serine/threonine kinase (ATR))
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别名
- ATR
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背景
- Background: ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.
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基因ID
- 545
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NCBI登录号
- NP_001175
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UniProt
- Q13535
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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