APOE 抗体 (Biotin)
Quick Overview for APOE 抗体 (Biotin) (ABIN7449331)
抗原
See all APOE 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Goat anti-Human Apo E [B10] Antibody Biotin Conjugated
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免疫原
- Human Apolipoprotein E
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亚型
- IgG
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应用备注
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WB: 1:1,000 - 1:8,000
ELISA: 1:1,000 - 1:8,000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02 % Sodium azide, pH 7.2
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- APOE (Apolipoprotein E (APOE))
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别名
- ApoE
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背景
- Background: Apo E contains 299 amino acid residues. It is a 34-37 kDa glycosylated protein (Rall et al., 1983). Apo E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. Apo E has also been implicated in immune and nerve degeneration. It has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo E isoforms, Apo E4. The Apo E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.
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基因ID
- 348
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NCBI登录号
- NP_000032
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UniProt
- P02649
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途径
- Regulation of Cell Size, Lipid Metabolism
抗原
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