EGLN3 抗体 (AA 50-100)
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Quick Overview for EGLN3 抗体 (AA 50-100) (ABIN7449245)
抗原
See all EGLN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 50-100
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原理
- Rabbit anti-PHD3 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 50 and 100
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亚型
- IgG
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应用备注
- 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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别名
- PHD3
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背景
- Background: PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
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基因ID
- 112399
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NCBI登录号
- NP_071356
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UniProt
- Q9H6Z9
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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