CSN3 抗体 (AA 325-375)
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北京 101111
Quick Overview for CSN3 抗体 (AA 325-375) (ABIN7448493)
抗原
See all CSN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 325-375
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原理
- Rabbit anti-CSN3 IHC Antibody, Affinity Purified
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预测反应
- Mouse,Rat,X. tropicalis,Chicken,Turkey,Bovine,Dog,Horse,Guinea pig_10141,Panda,Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Tasmanian devil,African elephant,Green anole,Small-eared galago,Gray short-tailed opossum,Naked mole rat,Chinese hamster,Thirteen-lined ground squirrel,Duckbill platypus,West Indian ocean coelacanth,Little brown bat,Zebra finch,Northern white-cheeked gibbon
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纯化方法
- Affinity Purified
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免疫原
- Between AA 325 and 375
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亚型
- IgG
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应用备注
- 1:100 - 1:500
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限制
- 仅限研究用
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浓度
- 250 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- CSN3 (Casein kappa (CSN3))
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别名
- CSN3
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背景
- Background: CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
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基因ID
- 8533
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NCBI登录号
- NP_003644
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UniProt
- Q9UNS2
抗原
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