HSP90 alpha/beta 抗体
Quick Overview for HSP90 alpha/beta 抗体 (ABIN7384453)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Affinity Purified
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亚型
- IgG
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anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (AA 291-304) antibody
HSP90 alpha/beta 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal Hyb-K41220A unconjugated
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (AA 291-304) antibody (FITC)HSP90 alpha/beta 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal Hyb-K41220A FITC
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (AA 291-304) antibody (Biotin)HSP90 alpha/beta 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal Hyb-K41220A Biotin
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (AA 291-304) antibody (Atto 488)HSP90 alpha/beta 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal Hyb-K41220A Atto 488
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (AA 291-304) antibody (Atto 594)HSP90 alpha/beta 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal Hyb-K41220A Atto 594
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (AA 291-304) antibody (Atto 390)HSP90 alpha/beta 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal Hyb-K41220A Atto 390
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) antibodyHSP90 alpha/beta 适用: 人, 大鼠, Saccharomyces cerevisiae, Schizosaccharomyces pombe WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal Hyb-K41220A unconjugated
anti-Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) (N-Term) antibodyHSP90 alpha/beta 适用: 人, 小鼠, Cow WB, IHC (p) 宿主: 小鼠 Monoclonal MBH90AB unconjugated
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应用备注
- WB 1:1000-1:2000 IHC 1:50-1:200 IF 1:50-1:200
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限制
- 仅限研究用
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浓度
- 300 μg/mL
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缓冲液
- 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- HSP90 alpha/beta (Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta))
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别名
- Hsp90 alpha/beta
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背景
- HSP84,HSPC2,HSPCB,D6S182,HSP90B,Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823).
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分子量
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Observed_MW: 90kDa
Calculated_MW: 85/83kDa
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基因ID
- 3326
抗原
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