OSBP2 抗体 (AA 221-320) (Cy5)
Quick Overview for OSBP2 抗体 (AA 221-320) (Cy5) (ABIN718080)
抗原
See all OSBP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 221-320
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交叉反应
- 人
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预测反应
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human OSBP2
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亚型
- IgG
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anti-Oxysterol Binding Protein 2 (OSBP2) (AA 818-916) antibody
OSBP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B4 unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- OSBP2 (Oxysterol Binding Protein 2 (OSBP2))
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别名
- OSBP2
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背景
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Synonyms: ORP 4, ORP4, OSBLP4, OSBP-related protein 4, OSBP2, OSBPL1, OSBPL4, Oxysterol Binding Protein 2, Oxysterol Binding Protein-like 1, oxysterol binding protein-related protein 4, OSBP2_HUMAN.
Background: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
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基因ID
- 23762
抗原
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