SMG7 抗体
Quick Overview for SMG7 抗体 (ABIN7384099)
抗原
See all SMG7 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human SMG7 (NP_963863.2).
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亚型
- IgG
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应用备注
- WB 1:200-1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SMG7 (Smg-7 Homolog, Nonsense Mediated mRNA Decay Factor (SMG7))
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别名
- SMG7
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背景
- SMG7,C1orf16,EST1C,SGA56M,This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD), a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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分子量
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Observed_MW: 127 kDa
Calculated_MW: 122 kDa/127 kDa/131 kDa
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基因ID
- 9887
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UniProt
- Q92540
抗原
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