Respiratory Syncytial Virus A Glycoprotein G (RSV A G) 抗体
The 小鼠 单克隆 anti-Respiratory Syncytial Virus A Glycoprotein G antibody (Clone 9H2G5C6) (ABIN7383844) specifically detects Respiratory Syncytial Virus A Glycoprotein G in ELISA.
The antibody is reactive with Respiratory Syncytial Virus (RSV) samples.
产品编号 ABIN7383844
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for Respiratory Syncytial Virus A Glycoprotein G (RSV A G) 抗体 (ABIN7383844)
抗原
Respiratory Syncytial Virus A Glycoprotein G (RSV A G)
适用
Respiratory Syncytial Virus (RSV)
宿主
小鼠
克隆类型
单克隆
应用范围
ELISA
克隆位点
9H2G5C6
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特异性
- Anti-Human respiratory syncytial virus(RSV) Glycoprotein G/RSV-G Monoclonal Antibody
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纯化方法
- Protein A Affinity
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免疫原
- Recombinant RSV (A, rsb1734) glycoprotein G / RSV-G Protein (95% Homology) (His Tag), ABIN7198762
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亚型
- IgG1
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应用备注
- ELISA 1:1000-1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- 0.2 μm filtered solution in PBS
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Respiratory Syncytial Virus A Glycoprotein G (RSV A G)
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别名
- respiratory syncytial virus(RSV) Glycoprotein G/RSV-G
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背景
- G,Glycoprotein,Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 8-9 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities.
抗原
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