tau 抗体 (AA 297-391) (APC)
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Quick Overview for tau 抗体 (AA 297-391) (APC) (ABIN7272119)
抗原
See all tau 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 297-391
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原理
- Rabbit Anti-Human Truncated Tau Fragment (AA297-391) (dGAE) Polyclonal,
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特异性
- Widely expressed, with high levels in brain.,Detects ~10.2 kDa.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Protein A
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免疫原
- Recombinant Human Tau AA297-391 (dGAE) Fibril (SPR-461)
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anti-tau Protein (pSer396) antibody
适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tau Protein (AA 677-707) antibody适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-tau Protein antibody适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 12F4 unconjugated
anti-tau Protein (AA 681-758) antibody适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-tau Protein antibody (PerCP)适用: 人 WB, ELISA, IF, ICC, DB 宿主: 小鼠 Monoclonal 1D5 PerCP
anti-tau Protein antibody (PE)适用: 人 WB, ELISA, IF, ICC, DB 宿主: 小鼠 Monoclonal 1D5 PE
anti-tau Protein (pSer202), (pThr205) antibody (Atto 390)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 Atto 390
anti-tau Protein (pSer202), (pThr205) antibody (Atto 594)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 Atto 594
anti-tau Protein (pSer202), (pThr205) antibody (APC)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 APC
anti-tau Protein (pSer202), (pThr205) antibody (Biotin)适用: 人 WB, ELISA, IHC, IF, ICC, DB 宿主: 兔 Monoclonal AH36 Biotin
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应用备注
- WB (1:1000), optimal dilutions for assays should be determined by the user.
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说明
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A 1:1000 dilution was sufficient for detection of tau in 15 μg of mouse, rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Conjugated antibodies should be stored at 4°C
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- tau (tau Protein)
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背景
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3)., cellular localisation: Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex
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基因ID
- 4137
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NCBI登录号
- NP_005901
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UniProt
- P10636
抗原
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