Recombinant SARS-CoV-2 Spike 抗体 (RBD) (PE)
Quick Overview for Recombinant SARS-CoV-2 Spike 抗体 (RBD) (PE) (ABIN7271728)
抗原
See all SARS-CoV-2 Spike 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- RBD
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原理
- PE-Labeled Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)
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特异性
- This product is a specific antibody specifically reacts with This product is a specific antibody against SARS-CoV-2 Spike protein RBD domain. No cross-reactivity is detected with Spike protein RBD domain of other coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.
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产品特性
- Recombinant Antibodies produced in HEK293. PE-Labeled Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 is isolated from a Spike RBD infected Mouse and is recombinantly produced from human 293 cells (HEK293)
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免疫原
- PE-Labeled Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) is a PE-labeled chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike S1 protein. As verified in ELISA, this chimeric monoclonal antibody can bind the spike protein of all SARS-CoV-2 Variants of Concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2).
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亚型
- IgG1
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应用备注
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Flow Cytometry (Neutralizing assay)
Conjugate
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
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限制
- 仅限研究用
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状态
- Powder
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储存条件
- -20 °C
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储存方法
- -20°C, avoid light
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- SARS-CoV-2 Spike
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背景
- It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
抗原
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